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Yoh Services LLC Senior Research Associate - Downstream in Wedgwood, Washington
Senior Research Associate - Downstream Category: Life Science Employment Type: Contract Reference: BH-375663 Sr Research Associate - Downstream External ID # 58975-1 Seattle, WA- ON SITE 12 month W2 contract (with potential to extend or transition to perm) Pay rate: $50-58/hour - Depending on Education and Experience Summary: The associate will join the LVV Platform Development team working on vector biology and molecular optimization initiatives intended to drive next-generation viral vector platform development. Specifically, in the pursuit of end-to-end assessment of novel technologies and approaches, the associate will seek to become highly proficient in downstream purification of lentiviral vectors, while gaining familiarity with LVV analytical methods and their interpretation in the context of LVV attributes and biology. The associate will also have the unique opportunity to be exposed to a wide range of highly novel molecular designs, and to work collaboratively with a range of different groups doing different types of LVV development. Responsibilities: Routine purification of LVV for platform fit assessment Execute and troubleshoot upstream and downstream process development experiments supporting next-generation LVV production Manage the flow of samples and data and perform analyses Assist in the design of experiments and interpretation of data Provide experimental design and executional support to team members in adjacent and related functions (e.g. clinical development programs, high throughput process development, etc.) Support research-to-development transition endeavors, including early-stage/pipeline molecular assessment activities Actively participate and support lab maintenance and continuous improvement initiatives Maintain accurate and detailed laboratory notebook and documentation Summarize and present data in group meetings and contribute to group discussions and team strategy Author technical reports and study memos Skills or Requirements: Experience with downstream processes development e.g. chromatography, filtration, TFF development, process-analytical technology (PAT) Experience with chromatography operation Experience with harvest filtration operation of biologics and/or viral vectors Experience with tangential flow filtration(TFF) or ultrafiltration/diafiltration(UF/DF) operation Experience in the development of viral vectors (e.g. adeno-, retro-, lenti-), including successful transfer for GMP manufacturing Basic Qualifications: Experience with purification of biologics (mAbs, fc-fusion proteins) or viral vectors Hands on experience in biologics process development Independently motivated with ability to work in teams Ability to communicate clearly and concisely through oral presentation and technical writing Ability to leverage literature, internal and external resources to solve problems Preferred Qualifications: Degree in biological, biomedical, or chemical engineering, biochemistry, or bio-related field Experience with AKTA chromatography skid operation Experience with tangential flow filtration or ultrafiltration/diafiltration operation Experience with depth filtration operation Experience with JMP for DoE design and analysis Experience in the development of viral vectors (e.g. adeno-, retro-, lenti-), including successful transfer for GMP manufacturing Experience with mammalian cell culture operation Experience with downstream platform processes development e.g. chromatography resin screens, TFF flux excursions, depth filter screens Education/Experience: STEM degree with 2+ years of relevant industry experience What's In It For You? We welcome you to be a part of one of the largest global staffing companies to meet your career aspirations. Yoh's network of client companies has b