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Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.

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Position Summary

We have developed an atlas of CAR-T cells using single-cell data from internal and external sources. This atlas provides a detailed understanding of CAR-T cell phenotypes, enriched signaling pathways, and their specific roles within the transduced T-cell population. The goal of this project is to develop a robust pipeline that incorporates quality control (QC) for query data and compare query data with reference data, such as Seurat label transferring method. This comparison will help estimate whether the query data is suitable for projection onto CAR-T single cell reference dataset. Additionally, the project will involve the development of a visualization tool to display QC results and projected cell type results, including mapping scores and projection scores. The tool will also visualize how cell types appear on both de novo UMAP and reference UMAP. This project aims to enhance the accuracy and reproducibility of cell type annotations by addressing dataset imbalances, detecting incompatibilities, and assessing cluster heterogeneity.

Key Responsibilities

• Pipeline Development for Data Quality Control:

• Design and implement an automated pipeline to perform QC on cell type annotation in query data after the label transfer step. This pipeline will systematically evaluate the accuracy and compatibility of transferred annotations, ensuring reliable and reproducible results.

• Comparative Analysis:

• Estimate the suitability of the query data for projection onto the reference dataset.

• Generate detailed reports on the comparative analysis.

• Visualization Tool Development:

• Create an interactive visualization tool to display QC results.

• Visualize projected cell type results, including mapping scores and projection scores.

• Develop UMAP visualizations to show how cell types appear on both de novo UMAP and reference UMAP.

Qualifications & Experience

• Proficiency in R programming language.

• Familiarity with single-cell RNA sequencing data analysis methods.

• Experience with data visualization libraries (e.g., ggplot2, Plotly).

• Ability to work with bioinformatics tools and packages, particularly those used for single cell analysis.

• Strong analytical and problem-solving skills.

• Excellent communication and documentation skills.

• Ability to work independently and as part of a team.

The starting compensation for this job is a range from $35.00/hour - $43.00/hour. The starting pay rate takes into account characteristics of the job, such as required skills and the geographic location where work is performed. Final individual compensation is decided commensurate with demonstrated experience and education level.

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as Transforming patients' lives through science™ , every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com . Visit careers.bms.com/ (https://careers.bms.com/eeo-accessibility) eeo-accessibility to access our complete Equal Employment Opportunity statement.

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BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

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Company: Bristol-Myers Squibb

Req Number: R1586138

Updated: 2024-10-06 04:15:15.302 UTC

Location: Seattle-WA

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.