Work in Washington Veterans Jobs

Req #: 241270

Department: BIOCHEMISTRY

Posting Date: 12/02/2024

Closing Info: Open Until Filled

Salary: $12,000 - $15,000 per month

Shift: First Shift

Notes: As a UW employee, you will enjoy generous benefits and work/life programs. For a complete description of our benefits for this position, please visit our website, click here. (https://hr.uw.edu/benefits/wp-content/uploads/sites/3/2018/02/benefits-professional-staff-librarians-academic-staff-20230701_a11y.pdf)

As a UW employee, you have a unique opportunity to change lives on our campuses, in our state and around the world. UW employees offer their boundless energy, creative problem-solving skills, and dedication to build stronger minds and a healthier world.

UW faculty and staff also enjoy outstanding benefits, professional growth opportunities and unique resources in an environment noted for diversity, intellectual excitement, artistic pursuits, and natural beauty.

The Department of Biochemistry has an outstanding opportunity for a Research Scientist/Engineer-Senior to join their team.

Field of research this position is engaged in: Computational protein design and massively parallel wet lab screening and optimization of de novo designed minibinders.

POSITION PURPOSE

The position leads professional research in the massively parallel wet lab screening an optimization of de novo computational protein minbinder designs, including their protein production and biophysical characterization. The research activities primarily involve wet lab activities as well as the management of technical support staff and coordination of numerous collaborative activities.

The position is devoted to scientific research, specifically the generation of chip encoded gene libraries for massively parallel wet lab screening of computationally Rosetta designed proteins. This involves simultaneously being actively involved in one or more ongoing research projects requiring the determination of the most suitable methods to be used in each project. The position uses professional judgment to determine which wet lab experiments are required to verify hypotheses on how best to design and screen large libraries of computationally designed proteins. This requires one to interpret experimental protein design results in collaboration with numerous other lab members, to determine whether they are consistent with experimental goals. The position requires ongoing review of pertinent literature for information that will further research goals. The position requires the preparation of research reports for presentation or publication. Works collaboratively with the IPD Director and several laboratory stakeholders to achieve complex research goals involving multiple laboratories.

DUTIES AND RESPONSIBILITIES Leads key collaborative projects in preparation and screening of de novo computationally designed protein libraries (40%)

• Collaboration with numerous researchers at the IPD in the design of new concepts, approaches and programs for preparation and screening of de novo computationally designed protein libraries.

• Manages complex multi-task projects in preparing and screening of de novo computationally designed protein libraries.

• Participates in complex projects with uncertain outcomes requiring analysis from multiple perspectives.

• Is able to direct projects with undefined timelines and communicate results in a timely manner.Methods Development (40%)

• Uses expert knowledge and judgment to develop new methods and techniques for obtaining solutions.

• Develops new methods in gene library construction, mininbinder screening, production, purification and assessment of the potential for anti-minibinder antibody immune responses from animal studies.Training (20%)

• Trains research staff, postdoctoral fellows and graduate students at the IPD in screening of de novo computationally designed protein libraries.

• Works with the RS Principal to direct the activities of technical support staff at the IPD in collaboration with other research staff. MINIMUM REQUIREMENTS

• Ph.D in Biochemistry or related field + seven or more years of experience in related field. Equivalent education/experience will substitute for all minimum qualifications except when there are legal requirements, such as a license/certification/registration. ADDITIONAL REQUIREMENTS

• Advanced expertise in protein design research, specifically wet lab preparation and screening of de novo computationally designed protein libraries, with a full understanding of the underlying principles and concepts. May be recognized as a leader in their area of expertise.

• Recognized as a resource for others to use in dealing with complex wet lab methods, equipment, processes, or procedures. Anticipates future needs in technology support.

• In-depth understanding of organizational structure both within and outside the work unit, including the role of each position in the group and in other groups.

• Ability to develop innovative processes to achieve goals. Directs others to develop essential tasks. Reviews work activities to determine where new information could improve processes or move projects forward.

• Proficient in preparation and screening of de novo computationally designed protein libraries. DESIRED QUALIFICATIONS

• Ph.D. degree in an appropriate field of science or technology or equivalent in education and experience AND total of seven (7) years research experience in computational protein research and wet lab methods for preparation and screening of de novo computationally designed protein libraries.

• Proven track record in complex research project leadership.

• Knowledge of biophysical methods for protein purification and biophysical characterization using AKTA, HPLC, SEC-MALS, CD, biolayer interferometry, SAXS, and others. Application Process: The application process may include completion of a variety of online assessments to obtain additional information that will be used in the evaluation process. These assessments may include Work Authorization, Cover Letter and/or others. Any assessments that you need to complete will appear on your screen as soon as you select “Apply to this position”. Once you begin an assessment, it must be completed at that time; if you do not complete the assessment, you will be prompted to do so the next time you access your “My Jobs” page. If you select to take it later, it will appear on your "My Jobs" page to take when you are access ready. Please note that your application will not be reviewed, and you will not be considered for this position until all required assessments have been completed.

University of Washington is an affirmative action and equal opportunity employer. All qualified applicants will receive consideration for employment without regard to, among other things, race, religion, color, national origin, sexual orientation, gender identity, sex, age, protected veteran or disabled status, or genetic information.