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Benaroya Research Institute Postdoctoral Research Associate in Seattle, Washington

Benaroya Research Institute at Virginia Mason is committed to winning the fight againstautoimmune diseases such as type 1 diabetes, rheumatoid arthritis, inflammatory bowel diseaseand multiple sclerosis, and immune system diseases such as allergies and asthma. BRI is an internationally recognized research institute that accelerates discovery by tackling questions from every angle, translating immunology breakthroughs into clinical therapiesand healthier patients. As a non-profit organization within the Virginia Mason Health System, BRI uniquely combines the expertise of a world-renowned medical research institute with the remarkable care of a healthcare quality leader.

The Diabetes Clinical Research Program at BRI maintains a biorepository ofhuman blood samples for the study of type 1 diabetes (T1D), with samples and patient histories under collection for 2 decades, alongside substantive immunological assay data. Wealso play a central role in national and international consortiaand clinical trial networks, with a focus on identifying biomarkers predictive of clinical outcomes in diabetes and identification of predictors of response to therapy. Specifically, BRI houses the chair of the NIH-funded Type 1 Diabetes TrialNet consortium, and sees study participants for TrialNet trials. By working closely with translational scientists at BRI, DCRPsupportsbroad efforts to understand the human immune system, how it changes in the context of autoimmunity, and what drives immune differences between healthy people.

This trainee will primarily focus on the Sound Life Project, a deep-dive into the human immune systema and how it changes as we age. The successful applicant will also work closely with staff in our Diabetes Clinical Research Program, learning about how we maintain our biobanks, recruit patients, and store associated clinical and scientific data. Ability to communicate scientific concepts to fellow investigators and lay people is a critical element of the position, both in talks and in writing. This role may involve some “bench time” but will primarily focus on writing and data analysis.

Duties include:

  • Maintain and analyze Sound Life Project mass cytometry datasets

  • Collaborate closely with BRI’s bioinformatics team to develop and streamline analytical approaches for Sound Life Project datasets, including mass cytometry, single cell RNAseq, and single cell ATACseq data

  • Query, clean, and share clinical datasets -especially for the Sound Life Project – but also other datasets including diabetes, COVID19, and other ongoing translational research studies

  • Collaborate with leaders in immunological research at BRI

  • Prepare literature reviews and data to aide in writing grants and publications; present data as needed

  • Learn and share knowledge about type 1 diabetes clinical research, specifically regarding trial outcomes and diabetes biomarkers

  • Track timelines for grants and pharma studies; aide in the preparation of progress reports

  • Perform other responsibilities as required

  • The successful applicant is a highly collaborative team player who welcomes challenges. Requires a Ph.D, preferably in immunology but related fields acceptable.

  • Prefer experience with flow and/or mass cytometry and exposure to large datasets.

  • Exposure to clinical research a plus, such as development of IRB protocols.

  • Attention to detail and science writing experience are required.

  • Training in statistical analysis would be beneficial but not required.

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, citizenship, disability or protected veteran status.

Requisition number: 2021-1665

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